Article
Separate GTP binding and GTPase activating domains of a G alpha subunit.
Science (New York, N.Y.) - 17 Dec 1993
Markby D W, Onrust R, Bourne H R
Abstract excerpt
Most members of the guanosine triphosphatase (GTPase) superfamily hydrolyze guanosine triphosphate (GTP) quite slowly unless stimulated by a GTPase activating protein or GAP. The alpha subunits (G alpha) of the heterotrimeric G proteins hydrolyze GTP much more rapidly and contain an approximately 120-residue insert not found in other GTPases. Interactions between a G alpha insert domain and a G alpha GTP-binding...
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