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Article

Angiogenesis and tumor growth inhibition by a matrix metalloproteinase inhibitor targeting radiation-induced invasion.

Molecular cancer therapeutics - 1 Nov 2005

Kaliski Alexandre, Maggiorella Laurence, Cengel Keith A, Mathe Denis, Rouffiac Valerie, Opolon Paule, Lassau Nathalie, Bourhis Jean, Deutsch Eric

Abstract excerpt

In this study, we have evaluated the interactions between ionizing radiation and a matrix metalloproteinase (MMP) inhibitor. Using Matrigel invasion assays, we show that ionizing radiation induced a dose-dependent increase in the invasive phenotype of cultured B16 melanoma cells and that conditioned medium from these irradiated B16 cells promoted endothelial cell [human microvascular endothelial cells (HMEC)]...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16275993
DOI: 10.1158/1535-7163.MCT-05-0179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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