Article
Enhanced radiosensitization and chemosensitization in NF-kappaB-suppressed human oral cancer cells via the inhibition of gamma-irradiation- and 5-FU-induced production of IL-6 and IL-8.
International journal of cancer - 1 Mar 2004
Tamatani Tetsuya, Azuma Masayuki, Ashida Yuki, Motegi Katsumi, Takashima Rina, Harada Koji, Kawaguchi Shin-ichi, Sato Mitsunobu
Abstract excerpt
We examined the mechanisms underlying the enhancement of radiosensitivity and chemosensitivity to gamma-irradiation (IR) and 5-Fluorouracil (5-FU) in human oral carcinoma cells (B88) in which NF-kappaB activity was constitutively suppressed. Three super-repressor form of IkappaBalpha cDNA-transfected cell (B88mI) clones and 1 empty vector-transfected cell clone (B88neo) have been established. We found that the...
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