Identification of Genes in Saccharomyces cerevisiae that Are Haploinsufficient for Overcoming Amino Acid Starvation.

doi:10.1534/g3.116.037416

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Article

Identification of Genes in Saccharomyces cerevisiae that Are Haploinsufficient for Overcoming Amino Acid Starvation.

G3 (Bethesda, Md.) - 3 Apr 2017

Bae Nancy S, Seberg Andrew P, Carroll Leslie P, Swanson Mark J

Abstract excerpt

The yeast Saccharomyces cerevisiae responds to amino acid deprivation by activating a pathway conserved in eukaryotes to overcome the starvation stress. We have screened the entire yeast heterozygous deletion collection to identify strains haploinsufficient for growth in the presence of sulfometuron methyl, which causes starvation for isoleucine and valine. We have discovered that cells devoid of MET15 are...

Topics

Amino Acids
Biological Assay
Genes, Fungal
Genetic Loci
Genetic Testing
Haploinsufficiency
Heterozygote
Loss of Heterozygosity
Molecular Sequence Annotation
Mutation
Phenotype
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 28209762
DOI: 10.1534/g3.116.037416
PMCID: PMC5386856

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