Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel mutation of the PTEN gene in a Japanese patient with Cowden syndrome and bilateral breast cancer.

Cancer genetics and cytogenetics - 1 Jul 2008

Tate Genshu, Suzuki Takao, Endo Yutaka, Mitsuya Toshiyuki

Abstract excerpt

Cowden syndrome (CS), also known as multiple hamartoma syndrome, is an autosomal dominant cancer syndrome associated with a high risk of breast and thyroid cancers. The phosphatase and tensin homolog gene (PTEN) encodes a lipid phosphatase that contains a PTPase domain and a C2 domain and plays a role as a tumor suppressor that negatively regulates the cell-survival signaling pathway initiated by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Base Sequence
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Hamartoma Syndrome, Multiple

Share to Polymerase Chain Reaction

Share to PTEN Phosphohydrolase

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 18558293
DOI: 10.1016/j.cancergencyto.2008.03.013

Genes

PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel mutation of the PTEN gene in a Japanese patient with Cowden syndrome and bilateral breast cancer.PMID 18558293Read ↗

Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.Semantic proximity Read ↗

Analysis of PTEN gene mutations in a Turkish patient with Cowden syndrome.Semantic proximity Read ↗

Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer.Semantic proximity Read ↗

Identification of a Cowden syndrome patient with a novel PTEN mutation and establishment of patient-derived induced pluripotent stem cells.Semantic proximity Read ↗

New mutation in the PTEN gene in a Brazilian patient with Cowden's syndrome.Semantic proximity Read ↗

PTEN hamartoma tumor syndrome: clinical risk assessment and management protocol.Semantic proximity Read ↗

A case of Cowden syndrome with a novel mutation in the PTEN gene.Semantic proximity Read ↗

Second malignant neoplasms in patients with Cowden syndrome with underlying germline PTEN mutations.Semantic proximity Read ↗

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation.Semantic proximity Read ↗

A case of Cowden syndrome diagnosed from multiple gastric polyposis.Semantic proximity Read ↗

Breast cancer risk and clinical implications for germline PTEN mutation carriers.Semantic proximity Read ↗

PTEN hamartoma tumor syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.