Article
Tetrad analysis shows that gene conversion is the major mechanism involved in mutation at the human minisatellite MS1 integrated in Saccharomyces cerevisiae.
Genetical research - 1 Feb 2000
Berg I, Cederberg H, Rannug U
Abstract excerpt
Minisatellites are arrays of tandemly repeated DNA sequences which occur at thousands of locations in the human genome. They are frequently hypervariable with respect to allele length as a result of high rates of complex and incompletely understood recombination-based germline mutation events that alter the repeat copy number. MS1 is one of the most variable minisatellites so far isolated from the human genome....
Topics
- Base Sequence
- DNA
- Gene Conversion
- Humans
- Minisatellite Repeats
- Molecular Sequence Data
- Mutation
- Saccharomyces cerevisiae