Article
Repeat unit sequence variation in minisatellites: a novel source of DNA polymorphism for studying variation and mutation by single molecule analysis.
Cell - 9 Feb 1990
Jeffreys A J, Neumann R, Wilson V
Abstract excerpt
Variation in internal minisatellite structure can be analyzed by mapping variant repeat units within amplified alleles. A system capable of distinguishing greater than 10(70) allelic states at the human hypervariable locus D1S8 has been developed. Population surveys of internal allelic structure...
Topics
- Alleles
- Base Sequence
- Chromosome Deletion
- DNA, Satellite
- Genetic Techniques
- Genetic Variation
- Haplotypes
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid
- Restriction Mapping
- Spermatozoa