Article
Increased apolipoprotein E expression correlates with the onset of neuronal degeneration in the spinal cord of G93A-SOD1 mice.
Neuroscience letters - 19 Dec 2002
Haasdijk Elize D, Vlug Angela, Mulder Monique T, Jaarsma Dick
Abstract excerpt
Apolipoprotein E (apoE) genotype is well known as a risk factor for Alzheimer's disease, but more recently also has been associated with the incidence or disease progression of other neurological diseases including amyotrophic lateral sclerosis (ALS). In the present study we have examined the distribution of apoE in the spinal cord of transgenic mice with a familial ALS-linked superoxide dismutase 1 (G93A-SOD1)...
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