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Article

Oxidative protein damage in cells engaged in beta-amyloidosis is related to apoE genotype.

Neuroreport - 25 Mar 2002

Mazur-Kolecka Bozena, Frackowiak Janusz, Kowal Dagmar, Krzeslowska Jolanta, Dickson Dennis

Abstract excerpt

The epsilon4 allele of apolipoprotein E (apoE) is a risk factor for Alzheimer's disease. The reduced antioxidant defense in epsilon4 carriers is suggested to contribute to beta-amyloidosis. We found that oxidative stress induced by treatment with Fe2+ ions raised more protein carbonyls in vascular smooth muscle cells isolated from human brains with apoE genotype epsilon4/epsilon4 than with 3epsilon/epsilon3 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11930162
DOI: 10.1097/00001756-200203250-00021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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