Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective reconstitution of human D4 dopamine receptor variants with Gi alpha subtypes.

Biochemistry - 4 Apr 2000

Kazmi M A, Snyder L A, Cypess A M, Graber S G, Sakmar T P

Abstract excerpt

G protein-coupled receptors (GPCRs) are seven-transmembrane (TM) helical proteins that bind extracellular molecules and transduce signals by coupling to heterotrimeric G proteins in the cytoplasm. The human D4 dopamine receptor is a particularly interesting GPCR because the polypeptide loop linking TM helices 5 and 6 (loop i3) may contain from 2 to 10 similar direct hexadecapeptide repeats. The precise role of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COS Cells
Share to Cytoplasm
Share to Genes, Synthetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to Peptide Fragments

Share to Protein Engineering

Share to Receptors, Dopamine D2

Share to Receptors, Dopamine D4

Source

Identifiers

PMID: 10736173
DOI: 10.1021/bi992354c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective reconstitution of human D4 dopamine receptor variants with Gi alpha subtypes.PMID 10736173Read ↗

Functional analysis of human D1 and D5 dopaminergic G protein-coupled receptors: lessons from mutagenesis of a conserved serine residue in the cytosolic end of transmembrane region 6.Semantic proximity Read ↗

Optimizing the Expression of Human Dopamine Receptors in Escherichia coli.Semantic proximity Read ↗

Functional activation by central monoamines of human dopamine D(4) receptor polymorphic variants coupled to GIRK channels in Xenopus oocytes.Semantic proximity Read ↗

Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes.Semantic proximity Read ↗

Probing the constitutive activity among dopamine D1 and D5 receptors and their mutants.Semantic proximity Read ↗

Identification of transmembrane regions critical for ligand binding to the human D3 dopamine receptor using various D3/D1 transmembrane chimeras.Semantic proximity Read ↗

A dopamine D2 receptor mutant capable of G protein-mediated signaling but deficient in arrestin binding.Semantic proximity Read ↗

Dopamine D5 receptor agonist high affinity and constitutive activity profile conferred by carboxyl-terminal tail sequence.Semantic proximity Read ↗

Comparative pharmacological and functional analysis of the human dopamine D4.2 and D4.10 receptor variants.Semantic proximity Read ↗

Constitutive activity of a chimeric D2/D1 dopamine receptor.Semantic proximity Read ↗

N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells.Semantic proximity Read ↗

An in vivo demonstration of functional G protein-coupled receptor dimers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.