Article
Paraoxonase PON1 polymorphism leu-Met54 is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study.
Stroke - 1 Oct 1998
Schmidt H, Schmidt R, Niederkorn K, Gradert A, Schumacher M, Watzinger N, Hartung H P, Kostner G M
Abstract excerpt
BACKGROUND AND PURPOSE: Genetic polymorphism at the paraoxonase locus is associated with serum concentration and activity of paraoxonase and with increased risk for coronary heart disease. Two frequent polymorphisms present at the paraoxonase gene are the methionine (M allele) leucine (L allele)...
Topics
- Aged
- Alleles
- Amino Acid Sequence
- Arteriosclerosis
- Aryldialkylphosphatase
- Austria
- Carotid Artery Diseases
- Cerebrovascular Disorders
- Esterases
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Risk Factors
- Ultrasonography, Doppler, Duplex