Article
Mutational screening of the INSL3 gene in azoospermic males with a history of cryptorchidism.
Andrologia - 1 Sept 2016
Huang X, Jia J, Sun M, Li M, Liu N
Abstract excerpt
The insulin-like factor 3 (INSL3 ) gene encodes 131 amino acids, consisting of two exons. In human beings, mutations of this gene may lead to bilateral cryptorchidism and infertility. However, the role of INSL3 in male spermatogenesis still remains controversial. We have analysed the coding sequence of INSL3 by PCR and DNA sequencing in 97 azoospermic patients with a history of bilateral cryptorchidism (patient...
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