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Article

Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism.

Urology - 1 Nov 2004

Feng Shu, Cortessis Victoria K, Hwang Andrew, Hardy Brian, Koh Chester J, Bogatcheva Natalia V, Agoulnik Alexander I

Abstract excerpt

OBJECTIVES: Male mice deficient in insulin-like 3 hormone (Insl3) or its receptor, Great/Lgr8, exhibit cryptorchidism. Recently, sequence analysis of the human INSL3 and GREAT genes identified several allelic variants. These include polymorphisms without apparent functional consequence and a few alleles encoding products with compromised function. However, loss-of-function alleles appear to be rare in human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 15533513
DOI: 10.1016/j.urology.2004.06.051

Genes

INSL3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism.PMID 15533513Read ↗

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Targeted Disruption of the Insl3 Gene Causes Bilateral CryptorchidismSemantic proximity Read ↗

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Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism.Semantic proximity Read ↗

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