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Article

Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese population.

Pediatrics international : official journal of the Japan Pediatric Society - 1 Jun 2001

Takahashi I, Takahashi T, Komatsu M, Matsuda J, Takada G

Abstract excerpt

BACKGROUND: Leydig insulin-like hormone (Insl3), a member of the insulin-like superfamily, is specifically expressed in Leydig cells of fetal and postnatal murine testis. Recently, the absence of the Insl3 gene has been reported to result in bilateral cryptorchidism in male mice and it has been s...

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Source

Identifiers

PMID: 11380919
DOI: 10.1046/j.1442-200x.2001.01390.x

Genes

INSL3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11380919-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese population.PMID 11380919Read ↗

Mutation and polymorphism analyses of INSL3 and LGR8/GREAT in 62 Japanese patients with cryptorchidism.Semantic proximity Read ↗

Different insulin-like 3 (INSL3) gene mutations not associated with human cryptorchidism.Semantic proximity Read ↗

Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism.Semantic proximity Read ↗

Mutational screening of the INSL3 gene in azoospermic males with a history of cryptorchidism.Semantic proximity Read ↗

Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism.Semantic proximity Read ↗

Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism.Semantic proximity Read ↗

Cryptorchidism in mice mutant for Insl3.Semantic proximity Read ↗

Novel mutations involving the INSL3 gene associated with cryptorchidism.Semantic proximity Read ↗

INSL3/LGR8 role in testicular descent and cryptorchidism.Semantic proximity Read ↗

Preliminary analysis of the G178A polymorphism of insulin-like factor 3 in male infertility.Semantic proximity Read ↗

The G178A polymorphic variant of INSL3 may be linked to cryptorchidism among Egyptian pediatric cohort.Semantic proximity Read ↗

Targeted Disruption of the Insl3 Gene Causes Bilateral CryptorchidismSemantic proximity Read ↗

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