Article
Biological function of the LH receptor is associated with slow receptor rotational diffusion.
Biochimica et biophysica acta - 5 Apr 2000
Roess D A, Brady C J, Barisas B G
Abstract excerpt
The biological activity of luteinizing hormone (LH) receptors can be affected by modifications to the receptor's amino acid sequence or by binding of hormone antagonists such as deglycosylated hCG. Here we have compared rotational diffusion of LH receptors capable of activating adenylate cyclase with that of non-functional hormone-occupied receptors at 4 degrees C and 37 degrees C using time-resolved...
Topics
- Animals
- Anisotropy
- Cell Line
- Chorionic Gonadotropin
- Cyclic AMP
- Diffusion
- Erythrosine
- Gene Expression
- Humans
- Kinetics
- Luminescent Measurements
- Luteinizing Hormone
- Mutation
- Rats
- Receptors, LH
- Rotation
- Structure-Activity Relationship
- Temperature
