Article
Both of the beta-subunit carbohydrate residues of follicle-stimulating hormone determine the metabolic clearance rate and in vivo potency.
Endocrinology - 1 Jun 1995
Bishop L A, Nguyen T V, Schofield P R
Abstract excerpt
FSH is a glycoprotein hormone required for the development and maturation of the ovarian follicle and for spermatogenesis. FSH is glycosylated at asparagine residues 52 and 78 on the alpha-subunit and residues 7 and 24 on the beta-subunit. In vitro, the carbohydrate residue at position alpha 52 is required for signal transduction. To define the contribution of the carbohydrate residues to FSH potency in vivo, we...
Topics
- Animals
- Carbohydrates
- Female
- Follicle Stimulating Hormone
- Genetic Variation
- Half-Life
- Humans
- In Vitro Techniques
- Male
- Organ Size
- Ovary
- Protein Conformation