Article
Progressive cytoplasmic tail truncations of the lutropin-choriogonadotropin receptor prevent agonist- or phorbol ester-induced phosphorylation, impair agonist- or phorbol ester-induced desensitization, and enhance agonist-induced receptor down-regulation.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 1996
Wang Z, Hipkin R W, Ascoli M
Abstract excerpt
Stably transfected human kidney 293 cells expressing the wild type rat LH/CG receptor (rLHR) or receptors with C-terminal tails truncated at residues 653, 631, or 628 (designated rLHR-t653, rLHR-t631, and rLHR-t628) were used to probe the importance of this region on the regulation of hormonal re...
Topics
- Binding Sites
- Chorionic Gonadotropin
- Clone Cells
- Cyclic AMP
- Cytoplasm
- Down-Regulation
- Humans
- Mutation
- Phorbol Esters
- Phosphorylation
- Receptors, LH
- Recombinant Proteins
- Transfection