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Article

Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse.

PloS one - 1 Jan 2012

Forbes Nicole E, Ping Jihui, Dankar Samar K, Jia Jian-Jun, Selman Mohammed, Keleta Liya, Zhou Yan, Brown Earl G

Abstract excerpt

The role of the NS1 protein in modulating influenza A virulence and host range was assessed by adapting A/Hong Kong/1/1968 (H3N2) (HK-wt) to increased virulence in the mouse. Sequencing the NS genome segment of mouse-adapted variants revealed 11 mutations in the NS1 gene and 4 in the overlapping NEP gene. Using the HK-wt virus and reverse genetics to incorporate mutant NS gene segments, we demonstrated that all...

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Identifiers

PMID: 22363747
DOI: 10.1371/journal.pone.0031839
PMCID: PMC3283688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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