Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infectious cDNA clones of Langat tick-borne flavivirus that differ from their parent in peripheral neurovirulence.

Virology - 30 Mar 2000

Campbell M S, Pletnev A G

Abstract excerpt

Tick-borne flavivirus strain Langat TP21 (LGT TP21) recovered from ticks, is naturally attenuated for humans but retains demonstrable neurovirulence and peripheral virulence ("neuroinvasiveness") for mice. Previously a mutant, strain E5, less virulent for mice was derived from LGT TP21. Multiple attempts to prepare a full-length infectious TP21 cDNA from cDNA fragments cloned in E. coli were uniformly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Consensus Sequence
Share to DNA, Complementary
Share to Encephalitis, Tick-Borne

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Encephalitis Viruses, Tick-Borne

Share to Genome, Viral

Share to Lethal Dose 50

Share to Mice, SCID

Share to Virus Replication

Source

Identifiers

PMID: 10725214
DOI: 10.1006/viro.2000.0220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infectious cDNA clones of Langat tick-borne flavivirus that differ from their parent in peripheral neurovirulence.PMID 10725214Read ↗

Infectious cDNA Clone of Attenuated Langat Tick-Borne Flavivirus (Strain E5) and a 3′ Deletion Mutant Constructed from It Exhibit Decreased Neuroinvasiveness in Immunodeficient MiceSemantic proximity Read ↗

Infectious cDNA clones of tick-borne encephalitis virus European subtype prototypic strain Neudoerfl and high virulence strain Hypr.Semantic proximity Read ↗

Spontaneous and Engineered Deletions in the 3′ Noncoding Region of Tick-Borne Encephalitis Virus: Construction of Highly Attenuated Mutants of a FlavivirusSemantic proximity Read ↗

A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice.Semantic proximity Read ↗

Construction of a CMV promoter-driven Langat virus cDNA clone and reporter virusesSemantic proximity Read ↗

Development and analysis of a tick-borne encephalitis virus infectious clone using a novel and rapid strategySemantic proximity Read ↗

Characterization and complete genome sequences of high- and low-virulence variants of tick-borne encephalitis virusSemantic proximity Read ↗

Development of a Model System for Tick-Borne Flavivirus Persistence in HEK 293T CellsSemantic proximity Read ↗

A BHK-21 cell culture-adapted tick-borne encephalitis virus mutant is attenuated for neuroinvasiveness.Semantic proximity Read ↗

The degree of attenuation of tick-borne encephalitis virus depends on the cumulative effects of point mutations.Semantic proximity Read ↗

A simple method for developing an infectious cDNA clone of Japanese encephalitis virus.Semantic proximity Read ↗

Amino acid changes responsible for attenuation of virus neurovirulence in an infectious cDNA clone of the Oshima strain of Tick-borne encephalitis virusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.