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Characterization and complete genome sequences of high- and low-virulence variants of tick-borne encephalitis virus

1 May 1996

Abstract excerpt

The entire genomic sequences of two strains (Hypr and 263) of the flavivirus tick-borne encephalitis (TBE) virus differing in virulence from the prototypic strain Neudoerfl were determined. Strain Hypr is a human isolate of TBE virus with a high laboratory passage history which exhibits a significantly higher neuro-invasiveness in mice compared to the prototype strain. Strain 263 is a low-passage tick-isolate...

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PMID: 8609469
DOI: 10.1099/0022-1317-77-5-1035

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