Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice.

Journal of virology - 1 Feb 2006

Rumyantsev Alexander A, Murphy Brian R, Pletnev Alexander G

Abstract excerpt

Langat virus (LGT), the naturally attenuated member of the tick-borne encephalitis virus (TBEV) complex, was tested extensively in clinical trials as a live TBEV vaccine and was found to induce a protective, durable immune response; however, it retained a low residual neuroinvasiveness in mice and humans. In order to ablate or reduce this property, LGT mutants that produced a small plaque size or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Encephalitis, Tick-Borne
Share to Encephalitis Viruses, Tick-Borne

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, SCID

Share to Neuroblastoma

Share to Vaccines, Attenuated

Share to Vero Cells

Share to Viral Envelope Proteins

Share to Viral Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 16415020
DOI: 10.1128/JVI.80.3.1427-1439.2006
PMCID: PMC1346960

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice.PMID 16415020Read ↗

Infectious cDNA Clone of Attenuated Langat Tick-Borne Flavivirus (Strain E5) and a 3′ Deletion Mutant Constructed from It Exhibit Decreased Neuroinvasiveness in Immunodeficient MiceSemantic proximity Read ↗

Infectious cDNA clones of Langat tick-borne flavivirus that differ from their parent in peripheral neurovirulence.Semantic proximity Read ↗

SiRNA Inhibits Replication of Langat Virus, a Member of the Tick-Borne Encephalitis Virus Complex in Organotypic Rat Brain SlicesSemantic proximity Read ↗

A BHK-21 cell culture-adapted tick-borne encephalitis virus mutant is attenuated for neuroinvasiveness.Semantic proximity Read ↗

The influence of the pre-membrane and envelope proteins on structure, pathogenicity and tropism of tick-borne encephalitis virusSemantic proximity Read ↗

Spontaneous and Engineered Deletions in the 3′ Noncoding Region of Tick-Borne Encephalitis Virus: Construction of Highly Attenuated Mutants of a FlavivirusSemantic proximity Read ↗

Genetic determinants of Sindbis virus neuroinvasivenessSemantic proximity Read ↗

The degree of attenuation of tick-borne encephalitis virus depends on the cumulative effects of point mutations.Semantic proximity Read ↗

Amino acid changes responsible for attenuation of virus neurovirulence in an infectious cDNA clone of the Oshima strain of Tick-borne encephalitis virusSemantic proximity Read ↗

Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir.Semantic proximity Read ↗

The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protectionSemantic proximity Read ↗

West Nile 25A virus infection of B-cell-deficient ((micro)MT) mice: characterization of neuroinvasiveness and pseudoreversion of the viral envelope protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.