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Article

The degree of attenuation of tick-borne encephalitis virus depends on the cumulative effects of point mutations.

The Journal of general virology - 1 Jul 2001

Gritsun T S, Desai A, Gould E A

Abstract excerpt

An infectious clone (pGGVs) of the tick-borne encephalitis complex virus Vasilchenko (Vs) was constructed previously. Virus recovered from pGGVs produced slightly smaller plaques than the Vs parental virus. Sequence analysis demonstrated five nucleotide differences between the original Vs virus and pGGVs; four of these mutations resulted in amino acid substitutions, while the fifth mutation was located in the 3'...

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PMID: 11413378
DOI: 10.1099/0022-1317-82-7-1667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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