Article
A BHK-21 cell culture-adapted tick-borne encephalitis virus mutant is attenuated for neuroinvasiveness.
Vaccine - 8 Sept 2003
Goto Akiko, Hayasaka Daisuke, Yoshii Kentarou, Mizutani Tetsuya, Kariwa Hiroaki, Takashima Ikuo
Abstract excerpt
We derived the baby hamster kidney (BHK)-21 cell culture-adapted, tick-borne encephalitis (TBE) virus mutant. To reveal the pathogenicity of the TBE virus, we compared the pathogenicity of the mutant (Oshima Cl-1) and parental (Oshima 5-10) virus in mouse model. The neurovirulence of mutant in mice was identical to that of parent. However, the level of neuroinvasiveness was higher for parent than for mutant. The...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Viral
- Brain
- Cell Line
- Cricetinae
- Encephalitis Viruses, Tick-Borne
- Encephalitis, Tick-Borne
- Gene Products, gag
- Genome, Viral
- Hemagglutination Tests
- Male
- Mice
- Mice, Inbred ICR