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Article

A BHK-21 cell culture-adapted tick-borne encephalitis virus mutant is attenuated for neuroinvasiveness.

Vaccine - 8 Sept 2003

Goto Akiko, Hayasaka Daisuke, Yoshii Kentarou, Mizutani Tetsuya, Kariwa Hiroaki, Takashima Ikuo

Abstract excerpt

We derived the baby hamster kidney (BHK)-21 cell culture-adapted, tick-borne encephalitis (TBE) virus mutant. To reveal the pathogenicity of the TBE virus, we compared the pathogenicity of the mutant (Oshima Cl-1) and parental (Oshima 5-10) virus in mouse model. The neurovirulence of mutant in mice was identical to that of parent. However, the level of neuroinvasiveness was higher for parent than for mutant. The...

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Identifiers

PMID: 12922141
DOI: 10.1016/s0264-410x(03)00269-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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