Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response

Abstract excerpt

The acute-phase response (APR) leads to alterations in lipid metabolism and type II nuclear hormone receptors, which regulate lipid metabolism, are suppressed, in liver, heart, and kidney. Here, we examine the effect of the APR in adipose tissue. In mice, lipopolysaccharide produces a rapid, marked decrease in mRNA levels of nuclear hormone receptors [peroxisome proliferator-activated receptor gamma (PPARgamma),...

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• Share to Adipokines, Inflammation, and Metabolic Diseases
• Share to Adipose Tissue and Metabolism
• Share to Lipid metabolism and biosynthesis