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Article

Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1.

The Journal of biological chemistry - 19 Sept 2003

Bowen Holly, Lapham Abigail, Phillips Emma, Yeung Irene, Alter-Koltunoff Michal, Levi Ben-Zion, Perry V Hugh, Mann Derek A, Barton C Howard

Abstract excerpt

Murine Nramp1 encodes a divalent cation transporter that is expressed in late endosomes/lysosomes of macrophages, and the transported cations facilitate intracellular pathogen growth control. The Nramp1 promoter is TATA box-deficient, has two initiator elements, and is repressed by c-Myc, in accordance with the notion that genes that deplete the iron content of the cell cytosol antagonize cell growth. Repression...

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Identifiers

PMID: 12840021
DOI: 10.1074/jbc.M304301200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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