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Article

Meta-analysis suggests association of L-myc EcoRI polymorphism with cancer prognosis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2004

Spinola Monica, Pedotti Paola, Dragani Tommaso A, Taioli Emanuela

Abstract excerpt

The L-myc EcoRI polymorphism is a noncoding variation in the second intron of the L-myc gene, resulting in S and L alleles. Individuals carrying the S allele tend to have poor prognosis and increased risk of several tumor types, although controversial results have been reported. A meta-analysis of 36 studies on L-myc EcoRI genotyping, including 3563 patients with different types of cancer and 2953 controls, was...

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PMID: 15269151
DOI: 10.1158/1078-0432.CCR-04-0055

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