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Article

E-cadherin is a biomarker for ferroptosis sensitivity in diffuse gastric cancer.

Oncogene - 1 Mar 2023

Minikes Alexander M, Song Yu, Feng Yan, Yoon Changhwan, Yoon Sam S, Jiang Xuejun

Abstract excerpt

Gastric cancer is the third most common cause of cancer-related death worldwide. Diffuse-type gastric cancer (DGC) is a particularly aggressive subtype that is both difficult to detect and treat. DGC is distinguished by weak cell-cell cohesion, most often due to loss of the cell adhesion protein E-cadherin, a common occurrence in highly invasive, metastatic cancer cells. In this study, we demonstrate that...

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Identifiers

PMID: 36717701
DOI: 10.1038/s41388-023-02599-5
PMCID: PMC10291936

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