Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.

Molecular and cellular biology - 1 Sept 2011

Ruediger Ralf, Ruiz Jennifer, Walter Gernot

Abstract excerpt

Strong evidence has indicated that protein phosphatase 2A (PP2A) is a tumor suppressor, but a mouse model for testing the tumor suppressor activity was missing. The most abundant forms of trimeric PP2A holoenzyme consist of the scaffolding Aα subunit, one of several regulatory B subunits, and the catalytic Cα subunit. Aα mutations were discovered in a variety of human carcinomas. All carcinoma-associated mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

Share to Incidence

Share to Protein Isoforms

Share to Protein Phosphatase 2

Share to Protein Subunits

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21791616
DOI: 10.1128/MCB.05744-11
PMCID: PMC3165721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.PMID 21791616Read ↗

Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene.Semantic proximity Read ↗

Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms.Semantic proximity Read ↗

A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A.Semantic proximity Read ↗

Germline mutations in PPP2R1B in patients with a personal and family history of cancer.Semantic proximity Read ↗

Mutagenesis and expression of the scaffolding Aalpha and Abeta subunits of PP2A: assays for measuring defects in binding of cancer-related Aalpha and Abeta mutants to the regulatory B and catalytic C subunits.Semantic proximity Read ↗

Suppression of PP2A-B56α drives EMT in EGFR mutant non-small cell lung cancer.Semantic proximity Read ↗

Functional importance of PP2A regulatory subunit loss in breast cancer.Semantic proximity Read ↗

B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activity.Semantic proximity Read ↗

The role of PP2A A subunits in tumor suppression.Semantic proximity Read ↗

Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis.Semantic proximity Read ↗

Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours.Semantic proximity Read ↗

Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.