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Article

Purification and characterization of DnaC810, a primosomal protein capable of bypassing PriA function.

The Journal of biological chemistry - 17 Mar 2000

Xu L, Marians K J

Abstract excerpt

Escherichia coli strains lacking PriA are severely compromised in their ability to repair UV-damaged DNA and to perform homologous recombination. These phenotypes arise because of a lack of PriA-directed replication fork assembly at recombination intermediates such as D-loops. Naturally arising suppressor mutations in dnaC restore strains carrying the priA2::kan null allele to wild-type function. We have cloned...

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Share to Bacteriophage phi X 174
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10713144
DOI: 10.1074/jbc.275.11.8196

Genes

SSB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Purification and characterization of DnaC810, a primosomal protein capable of bypassing PriA function.PMID 10713144Read ↗

Mutational Analysis of Residues in PriA and PriC Affecting Their Ability To Interact with SSB in Escherichia coli K-12.Semantic proximity Read ↗

dnaC mutations suppress defects in DNA replication- and recombination-associated functions in priB and priC double mutants in Escherichia coli K-12.Semantic proximity Read ↗

The DNA replication priming protein, PriA, is required for homologous recombination and double-strand break repair.Semantic proximity Read ↗

Differential suppression of priA2::kan phenotypes in Escherichia coli K-12 by mutations in priA, lexA, and dnaC.Semantic proximity Read ↗

Escherichia coli K-12 has two distinguishable PriA-PriB replication restart pathways.Semantic proximity Read ↗

Biochemical characterization of Escherichia coli DnaC variants that alter DnaB helicase loading onto DNA.Semantic proximity Read ↗

A novel dnaC mutation that suppresses priB rep mutant phenotypes in Escherichia coli K-12.Semantic proximity Read ↗

PriA mutations that affect PriA-PriC function during replication restart.Semantic proximity Read ↗

ATPase-deficient mutants of the Escherichia coli DNA replication protein PriA are capable of catalyzing the assembly of active primosomes.Semantic proximity Read ↗

Crystal structure and DNA-binding mode of Klebsiella pneumoniae primosomal PriB protein.Semantic proximity Read ↗

A structural model of the PriB-DnaT complex in Escherichia coli replication restart.Semantic proximity Read ↗

A dnaT mutant with phenotypes similar to those of a priA2::kan mutant in Escherichia coli K-12.Semantic proximity Read ↗

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