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Article

Fidelity of human DNA polymerase eta.

The Journal of biological chemistry - 17 Mar 2000

Johnson R E, Washington M T, Prakash S, Prakash L

Abstract excerpt

Xeroderma pigmentosum (XP) patients are highly sensitive to sunlight, and they suffer from a high incidence of skin cancers. The variant form of XP results from mutations in the hRAD30A gene, which encodes the DNA polymerase in humans, hPol(eta). Of the eukaryotic DNA polymerases, only human Pol(eta) and its yeast counterpart have the ability to replicate DNA containing a cis-syn thymine-thymine (T-T) dimer. Here...

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Identifiers

PMID: 10713043
DOI: 10.1074/jbc.275.11.7447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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