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Article

Bias and efficiency in family-based gene-characterization studies: conditional, prospective, retrospective, and joint likelihoods.

American journal of human genetics - 1 Mar 2000

Kraft P, Thomas D C

Abstract excerpt

We revisit the usual conditional likelihood for stratum-matched case-control studies and consider three alternatives that may be more appropriate for family-based gene-characterization studies: First, the prospective likelihood, that is, Pr(D/G,A second, the retrospective likelihood, Pr(G/D); and third, the ascertainment-corrected joint likelihood, Pr(D,G/A). These likelihoods provide unbiased estimators of...

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Identifiers

PMID: 10712222
DOI: 10.1086/302808
PMCID: PMC1288146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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