Article
A genome screen of multiplex sibships with prostate cancer.
American journal of human genetics - 1 Mar 2000
Suarez B K, Lin J, Burmester J K, Broman K W, Weber J L, Banerjee T K, Goddard K A, Witte J S, Elston R C, Catalona W J
Abstract excerpt
Analysis of a genome screen of 504 brothers with prostate cancer (CaP) who were from 230 multiplex sibships identified five regions with nominally positive linkage signals, on chromosomes 2q, 12p, 15q, 16p, and 16q. The strongest signal in these data is found on chromosome 16q, between markers D16S515 and D16S3040, a region suspected to contain a tumor-suppressor gene. On the basis of findings from previous...
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