Article
Linkage analyses at the chromosome 1 loci 1q24-25 (HPC1), 1q42.2-43 (PCAP), and 1p36 (CAPB) in families with hereditary prostate cancer.
American journal of human genetics - 1 Feb 2000
Berry R, Schaid D J, Smith J R, French A J, Schroeder J J, McDonnell S K, Peterson B J, Wang Z Y, Carpten J D, Roberts S G, Tester D J, Blute M L, Trent J M, Thibodeau S N
Abstract excerpt
Recent studies suggest that hereditary prostate cancer (PRCA) is a complex disease, involving multiple susceptibility genes and variable phenotypic expression. Through linkage analysis, potential prostate cancer susceptibility loci have been mapped to 3 regions on chromosome 1. To investigate the reported linkage to these regions, we conducted linkage studies on 144 PRCA families by using microsatellite markers...
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