Article
Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics.
American journal of human genetics - 1 Jan 2002
Mayeux R, Lee J H, Romas S N, Mayo D, Santana V, Williamson J, Ciappa A, Rondon H Z, Estevez P, Lantigua R, Medrano M, Torres M, Stern Y, Tycko B, Knowles J A
Abstract excerpt
Linkage to chromosome 12p for familial Alzheimer disease (AD) has been inconsistent. Using 35 markers near the centromere of chromosome 12, we investigated 79 Caribbean Hispanic families with AD. Two-point linkage analysis using affected sib pairs yielded LOD scores of 3.15 at D12S1623 and 1.43 at D12S1042. The LOD score at D12S1623 decreased to 1.62 in families with late-onset (age >65 years) AD (LOAD), but the...
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