Article
Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.
JAMA - 19 Aug 1998
Rogaeva E, Premkumar S, Song Y, Sorbi S, Brindle N, Paterson A, Duara R, Levesque G, Yu G, Nishimura M, Ikeda M, O'Toole C, Kawarai T, Jorge R, Vilarino D, Bruni A C, Farrer L A, St George-Hyslop P H
Abstract excerpt
CONTEXT: Alzheimer disease (AD) susceptibility genes have been identified on chromosomes 1, 14, 19, and 21, and a recent study has suggested a locus on chromosome 12. OBJECTIVE: To confirm or refute the existence of a familial AD susceptibility locus on chromosome 12 in an independent sample of f...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoproteins E
- Chromosome Mapping
- Chromosomes, Human, Pair 12
- DNA
- Female
- Genetic Linkage
- Genotype
- Humans
- Lod Score
- Male
- Middle Aged