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Article

Detection of BRCA1 and BRCA2 mutations in breast cancer families by a comprehensive two-stage screening procedure.

International journal of cancer - 15 Feb 2000

Spitzer E, Abbaszadegan M R, Schmidt F, Hauser A, Buwitt U, Lauter F R, Pötschick K, Krocker J, Elling D, Grosse R

Abstract excerpt

We have developed a 2-stage protocol for BRCA1 and BRCA2 mutation screening from blood spot paper. Stage 1 screening was aimed to analyze patients at highest risk for the most common disease-associated sequence variants listed in the BIC database. Accordingly, stage1 testing implied detection of 18 disease- associated BRCA1 and 9 BRCA2 mutations by adapting the 5' nuclease assay to heterozygote screening. For...

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Source

Identifiers

PMID: 10699917
DOI: 10.1002/(sici)1097-0215(20000215)85:4<474::aid-ijc5>3.0.co;2-4

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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