Article
High throughput fluorescence-based conformation-sensitive gel electrophoresis (F-CSGE) identifies six unique BRCA2 mutations and an overall low incidence of BRCA2 mutations in high-risk BRCA1-negative breast cancer families.
Human genetics - 1 May 1998
Ganguly T, Dhulipala R, Godmilow L, Ganguly A
Abstract excerpt
Mutational analysis of cancer susceptibility genes has opened up a new era in clinical genetics. In this report we present the results of mutational analysis of the BRCA2 coding sequences in 105 high-risk individuals affected with breast cancer and/or ovarian cancer and previously found to be neg...
Topics
- Adult
- Aged
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Breast Neoplasms, Male
- DNA Mutational Analysis
- Disease Susceptibility
- Electrophoresis
- Evaluation Studies as Topic
- False Negative Reactions
- False Positive Reactions
- Female
- Fluorescence