Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis.

Nature genetics - 1 Dec 1996

Hacia J G, Brody L C, Chee M S, Fodor S P, Collins F S

Abstract excerpt

The ability to scan a large gene rapidly and accurately for all possible heterozygous mutations in large numbers of patient samples will be critical for the future of medicine. We have designed high-density arrays consisting of over 96,600 oligonucleotides 20-nucleotides (nt) in length to screen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Probes
Share to Fluorescence
Share to BRCA1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Carrier Screening

Share to Heterozygote

Share to Mutation

Share to Nucleic Acid Hybridization

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 8944024
DOI: 10.1038/ng1296-441

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8944024-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis.PMID 8944024Read ↗

Strategies for mutational analysis of the large multiexon ATM gene using high-density oligonucleotide arrays.Semantic proximity Read ↗

High-throughput polymorphism screening and genotyping with high-density oligonucleotide arrays.Semantic proximity Read ↗

Resequencing and mutational analysis using oligonucleotide microarrays.Semantic proximity Read ↗

Accessing genetic information with high-density DNA arrays.Semantic proximity Read ↗

Accessing single nucleotide polymorphisms in genomic DNA by direct multiplex polymerase chain reaction amplification on oligonucleotide microarrays.Semantic proximity Read ↗

Using oligonucleotide probe arrays to access genetic diversity.Semantic proximity Read ↗

Microarray-based method for genotyping of functional single nucleotide polymorphisms using dual-color fluorescence hybridization.Semantic proximity Read ↗

A fluorescent multiplex-DGGE screening test for mutations in the BRCA1 gene.Semantic proximity Read ↗

High-throughput mutation detection method to scan BRCA1 and BRCA2 based on heteroduplex analysis by capillary array electrophoresis.Semantic proximity Read ↗

Oligonucleotide arrays for high-throughput SNPs detection in the MHC class I genes: HLA-B as a model system.Semantic proximity Read ↗

High throughput parallel analysis of hundreds of patient samples for more than 100 mutations in multiple disease genes.Semantic proximity Read ↗

Determination of molecular markers for BRCA1 and BRCA2 heterozygosity using gene expression profiling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.