Article
A highly sensitive, fast, and economical technique for mutation analysis in hereditary breast and ovarian cancers.
Human mutation - 1 Jan 1999
Arnold N, Gross E, Schwarz-Boeger U, Pfisterer J, Jonat W, Kiechle M
Abstract excerpt
Mutation analysis of complex genes without hotspots for sequence variations, such as BRCA1, is time-consuming and expensive. Of all currently available methods, direct sequencing has the highest sensitivity, but also the highest costs. Other techniques, such as SSCP, DGGE, and PTT, are more economical but, depending on the experience of the investigator, have at best a sensitivity of 90%. We investigated in a...
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