Article
Molecular decipherment of Rho effector pathways regulating tight-junction permeability.
The Biochemical journal - 15 Mar 2000
Fujita H, Katoh H, Hasegawa H, Yasui H, Aoki J, Yamaguchi Y, Negishi M
Abstract excerpt
We reported recently that the activation of RhoA induced an increase in transepithelial electrical resistance (TER). To clarify effectors of Rho for this RhoA-induced regulation of tight-junction permeability, we introduced two effector-loop mutants of constitutively active RhoA(V14), RhoA(V14/L40) and RhoA(V14/C42), into Mardin-Darby canine kidney cells in an isopropyl beta-D-thiogalactoside-inducible expression...
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