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Article

Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP.

The Journal of biological chemistry - 20 Feb 2009

Mori Kazutaka, Amano Mutsuki, Takefuji Mikito, Kato Katsuhiro, Morita Yasuhiro, Nishioka Tomoki, Matsuura Yoshiharu, Murohara Toyoaki, Kaibuchi Kozo

Abstract excerpt

RhoA is transiently activated by specific extracellular signals such as endothelin-1 (ET-1) in vascular smooth muscle cells. RhoGAP negatively regulates RhoA activity: thus, RhoA becomes the GDP-bound inactive form afterward. Sustained activation of RhoA is induced with high doses of the extracellular signals and is implicated in certain diseases such as vasospasms. However, it remains largely unknown how...

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Source

Identifiers

PMID: 19103606
DOI: 10.1074/jbc.M806853200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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