Article
Mutagenic specificity of imidazole ring-opened 7-methylpurines in M13mp18 phage DNA.
Acta biochimica Polonica - 1 Jan 1999
Tudek B, Graziewicz M, Kazanova O, Zastawny T H, Obtułowicz T, Laval J
Abstract excerpt
The most abundant lesion formed in DNA upon modification with methylating agents 7-methylguanine, under alkaline conditions is converted into 2,6-diamino-4-hydroxy-5N-methyl-formamidopyrimidine (Fapy-7MeGua). We have previously shown that treatment of dimethylsulfate methylated DNA with NaOH crea...
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