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Article

K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs.

International journal of radiation oncology, biology, physics - 1 Dec 2011

Minjgee Minjmaa, Toulany Mahmoud, Kehlbach Rainer, Giehl Klaudia, Rodemann H Peter

Abstract excerpt

PURPOSE: It is known that postirradiation survival of tumor cells presenting mutated K-RAS is mediated through autocrine activation of epidermal growth factor receptor (EGFR). In this study the molecular mechanism of radioresistance of cells overexpressing mutated K-RAS(V12) was investigated. METHODS AND MATERIALS: Head-and-neck cancer cells (FaDu) presenting wild-type K-RAS were transfected with empty vector or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intercellular Signaling Peptides and Proteins

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Share to Proto-Oncogene Proteins c-akt

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Source

Identifiers

PMID: 21985943
DOI: 10.1016/j.ijrobp.2011.05.057

Genes

EGFR
AREG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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