Article
Functional association between the nef gene product and gag-pol region of HIV-1.
FEBS letters - 28 Jan 2000
Ono T, Iwatani Y, Nishimura A, Ishimoto A, Sakai H
Abstract excerpt
Nef gene function is diverse among virus isolates of primate immunodeficiency viruses. We found differential effects of nef mutation on the virus replication between two HIV-1 clones, NL432 and LAI. The nef mutation in NL432 affected the infectivity more severely compared with that in LAI, although the Nef functions of both clones were comparable. Analysis with a series of chimeric viruses between NL432 and LAI...
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