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Article

Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism.

Journal of virology - 1 Aug 2002

Papkalla Armin, Münch Jan, Otto Claas, Kirchhoff Frank

Abstract excerpt

We investigated the infectivities and replicative capacities of a large panel of variants of the molecular human immunodeficiency virus type 1 (HIV-1) NL4-3 clone that differ exclusively in the V3 region of the viral envelope glycoprotein and the nef gene. Our results demonstrate that Nef enhances virion infectivity and HIV-1 replication independently of the viral coreceptor tropism.

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Share to CD4-Positive T-Lymphocytes
Share to Genes, nef
Share to HIV Envelope Protein gp120

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, CCR5

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Source

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Identifiers

PMID: 12134048
DOI: 10.1128/jvi.76.16.8455-8459.2002
PMCID: PMC155138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism.PMID 12134048Read ↗

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