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Article

Glutathione S-transferase polymorphisms in MS: their relationship to disability.

Neurology - 8 Feb 2000

Mann C L, Davies M B, Boggild M D, Alldersea J, Fryer A A, Jones P W, Ko Ko C, Young C, Strange R C, Hawkins C P

Abstract excerpt

BACKGROUND: Oxidative stress has been implicated in inflammatory demyelination. The glutathione S-transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress. Certain GST loci are polymorphic, demonstrating alleles that are null (GSTM1/GSTT1), encode low activity variants (GSTP1), or are associated with variable inducibility (GSTM3). OBJECTIVES: To...

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Source

Identifiers

PMID: 10680782
DOI: 10.1212/wnl.54.3.552

Genes

GSTM1
GSTM3
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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