Article
Risk of acute promyelocytic leukemia in multiple sclerosis: coding variants of DNA repair genes.
Neurology - 22 Mar 2011
Hasan S K, Buttari F, Ottone T, Voso M T, Hohaus S, Marasco E, Mantovani V, Garagnani P, Sanz M A, Cicconi L, Bernardi G, Centonze D, Lo-Coco F
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) in double-strand break repair genes may alter DNA repair capacity and, in turn, confer predisposition to leukemia. We analyzed polymorphic variants of DNA repair and detoxification genes in patients with multiple sclerosis (MS) who developed secondary acute promyelocytic leukemia (sAPL), in most cases after treatment with mitoxantrone (MTZ). METHODS: Using...
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