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Article

Glutathione-S-transferase T1 and M1 gene polymorphisms in Greek patients with multiple sclerosis: a pilot study.

European journal of neurology - 1 May 2007

Stavropoulou C, Korakaki D, Rigana H, Voutsinas G, Polyzoi M, Georgakakos V N, Manola K N, Karageorgiou C E, Sambani C

Abstract excerpt

Oxidative stress has been implicated in the pathogenesis of multiple sclerosis (MS). Glutathione-S-transferases (GSTs) are detoxification enzymes, evolved to protect cells against reactive oxygen metabolites. Both GSTT1 and GSTM1 genes exhibit a homozygous deletion polymorphism (null genotype) leading to abolished enzyme activity. We studied the impact of the GSTT1 and GSTM1 polymorphisms on MS susceptibility in...

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Identifiers

PMID: 17437619
DOI: 10.1111/j.1468-1331.2006.01678.x

Genes

GSTM1
GSTT1

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