Article
Evidence for a high frequency of simultaneous double-nucleotide substitutions.
Science (New York, N.Y.) - 18 Feb 2000
Averof M, Rokas A, Wolfe K H, Sharp P M
Abstract excerpt
Point mutations are generally assumed to involve changes of single nucleotides. Nevertheless, the nature and known mechanisms of mutation do not exclude the possibility that several adjacent nucleotides may change simultaneously in a single mutational event. Two independent approaches are used here to estimate the frequency of simultaneous double-nucleotide substitutions. The first examines switches between TCN...
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