Article
Directionality of point mutation and 5-methylcytosine deamination rates in the chimpanzee genome.
BMC genomics - 13 Dec 2006
Jiang Cizhong, Zhao Zhongming
Abstract excerpt
BACKGROUND: The pattern of point mutation is important for studying mutational mechanisms, genome evolution, and diseases. Previous studies of mutation direction were largely based on substitution data from a limited number of loci. To date, there is no genome-wide analysis of mutation direction or methylation-dependent transition rates in the chimpanzee or its categorized genomic regions. RESULTS: In this study,...
Topics
- 5-Methylcytosine
- Animals
- Base Composition
- CpG Islands
- DNA Mutational Analysis
- Databases, Nucleic Acid
- Deamination
- Evolution, Molecular
- Exons
- Genome
- Genome, Human
- Humans